相关实验视频

Updated: Jul 9, 2025

Reliable and High Efficiency Extraction of Kidney Immune Cells

Reliable and High Efficiency Extraction of Kidney Immune Cells

Published on: August 19, 2016

慢性病患者循环B细胞亚种群的分布特征

Xuya Chen¹, Haoyang Guo¹, Danxia Jin¹

¹Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, 60 West Wuning Road, Dongyang, 322100, Zhejiang, China.

Scientific reports

|November 27, 2023

概括

慢性病 (CKD) 改变循环B细胞亚群,晚期显示过渡性和CD5+B细胞减少. 在末期病中,血液透析对这些免疫细胞的影响需要进一步研究.

科学领域:

免疫学免疫学免疫学
腎臟病學 (nephrology) 是一種醫學專業.
细胞生物学细胞生物学

背景情况:

慢性病 (CKD) 与免疫失调有关.
了解CKD中的B细胞动态对于管理免疫平衡至关重要.
功能下降对B细胞亚群的影响仍然不完全理解.

研究的目的:

为了比较不同CKD阶段的B细胞亚群.
调查血液透析 (HD) 对末期脏疾病 (ESRD) 中的B细胞简介的影响.
评估慢性病患者功能和免疫平衡之间的关系.

主要方法:

循环B细胞亚群的流动细胞计分析.
包括197名CKD患者 (包括HD患者在内的I-V阶段) 和77名健康对照.
在CKD阶段,健康对照和HD前/后之间比较B细胞分布.

主要成果:

与对照组相比,CKDV期患者的过渡性B细胞和CD5+B细胞减少,双阴性 (DN) B细胞增加.
晚期CKD阶段显示,各种B细胞亚群的绝对数量显著减少.
随着CKD的进展,B细胞亚群分布发生了显著的变化;HD对DN和CD5+B细胞的影响不一致.

结论:

循环B细胞亚群在CKD中显著改变,并与疾病进展有关.
在CKD中,免疫平衡被破坏,B细胞子集的特定变化.
对HD对B细胞概况的影响进行进一步的研究是有必要的,因为临床影响.

更多相关视频

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

相关概念视频

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...