代谢健康状况和脏疾病:一个横截面研究
Firouzeh Moeinzadeh1, Mohammad Hossein Rouhani2, Shiva Seirafian1
1Isfahan Kidney Diseases Research Center, Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Scientific reports
|November 27, 2023
概括
代谢不健康的超重和肥胖显著增加慢性病 (CKD) 的风险. 代谢综合征,特别是肥胖,提高了脏疾病的几率,强调了进一步研究的必要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 体重指数 (BMI) 与慢性病 (CKD) 的发展有关.
- 代谢综合征可能会改变BMI和CKD之间的关联.
- 了解与CKD相关的代谢健康状况至关重要.
研究的目的:
- 评估伊朗成年人代谢健康状况和CKD之间的关联.
- 研究不同代谢表型对功能的影响.
- 确定代谢综合征和肥胖在脏疾病中的作用.
主要方法:
- 对3322名伊朗成年人的横截面研究.
- 使用NCEP ATP III标准确定的代谢综合征.
- 通过eGFR (MDRD-EPI公式) 评估的CKD,白蛋白尿和血液尿.
- 表型:代谢健康的正常体重 (MHNW),代谢健康的超重/肥胖 (MHO),代谢不健康的正常体重 (MUHNW),代谢不健康的超重/肥胖 (MUHO).
主要成果:
- 代谢不健康的超重和肥胖 (MUHO) 显著增加了CKD风险 (OR: 1.48).
- MUHNW和MUHO表型与较低的eGFR和白色素尿有关.
- 与MHNW相比,MHO (OR: 1.42) 和MUHO (OR: 1.64) 表型中结石的发生率更高.
结论:
- 代谢综合征增加了脏疾病的几率,无论BMI.
- 代谢综合征和肥胖的结合加大了脏疾病的风险.
- 需要进一步的研究来证实这些发现,确定因果关系,并探索机制.
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