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Updated: Jul 9, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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将多种功能遗传编码到细胞外囊中,以便有针对性地将生物物质输送到T细胞

Devin M Stranford1,2, Lacy M Simons3,4, Katherine E Berman2,5

  • 1Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.

Nature biomedical engineering
|November 27, 2023
PubMed
概括

研究人员设计了细胞以产生细胞外囊泡 (EVs),以对T细胞进行有针对性的生物输送. 这种新的方法可以在没有化学修饰的情况下进行精确的输送,从而推进细胞免疫疗法.

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