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癌症中的免疫代谢生态系统

Glenn R Bantug¹, Christoph Hess^2,3

¹Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, Basel, Switzerland. glenn.bantug@unibas.ch.

Nature immunology

|November 27, 2023

概括

准癌症代谢是有希望的,但具有挑战性. 抑制癌细胞代谢可以意外地促进瘤生长和抑制免疫反应,需要更广泛的治疗方法.

科学领域:

在瘤学瘤学.
癌症新陈代谢癌症新陈代谢
瘤微环境瘤微环境

背景情况:

癌细胞利用独特的代谢途径生存和增殖.
将代谢洞察转化为有效的临床癌症疗法仍然是一个重大挑战.
瘤微环境,包括非恶性细胞,在癌症进展中起着至关重要的作用.

研究的目的:

审查癌细胞和非恶性瘤细胞之间的代谢相互作用.
检查向癌症代谢如何影响瘤生态系统.
强调在开发代谢向癌症疗法的过程中需要采用整体方法.

主要方法:

关于癌症代谢和瘤微环境的当前文献的综述.
恶性和非恶性细胞之间的代谢交叉的分析.
评估代谢抑制剂对瘤居民细胞和免疫功能的影响.

主要成果:

向癌细胞中的特定代谢酶可能会对非恶性细胞产生意想不到的后果.
抑制癌症代谢可能会促进瘤生长,并创造一种免疫抑制的微环境.
代谢干预可以损害瘤特异性T细胞的功能.

结论:

对瘤的代谢生态系统的全面了解对于有效的癌症治疗至关重要.
针对新陈代谢的抗癌策略必须考虑对所有瘤居民细胞的更广泛影响.
需要采用整体方法来提高针对癌症代谢的药物的疗效.

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