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在免疫系统中,X-CHIME可实现组合性,诱导性,基因特异性和序列性基因淘汰

Martin W LaFleur1,2, Ashlyn M Lemmen1,2, Ivy S L Streeter1,2

  • 1Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

Nature immunology
|November 27, 2023
PubMed
概括

X-CHIME系统能够在小鼠中进行快速的组合基因功能研究. 删除Ptpn1和Ptpn2导致死亡,揭示了它们在免疫细胞发育和成年人生存中的重要作用.

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