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在CAR T细胞中,FOXP1和KLF2相互调节干状向效应体转换的检查点

Ziang Zhu1,2, Guohua Lou3, Xiao-Lu Teng1

  • 1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature immunology
|November 27, 2023
PubMed
概括

类似CD8+ T细胞的干细胞对于免疫治疗至关重要. 这项研究确定了关键的转录因子和基因网络,如FOXP1和KLF2,这些基因控制着化学抗原受体 (CAR) T细胞的分化,使其进入干状,效应器或耗尽状态.

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