全球南方不断增长的制药创新:一个景观研究
Marcela Vieira1, Tatiana Andia2, Obaida Karim3
1Global Health Centre, Geneva Graduate Institute, Maison de La Paix, Chemin Eugène-Rigot 2, 1202, Geneva, Switzerland. marcela.vieira@graduateinstitute.ch.
Journal of pharmaceutical policy and practice
|November 28, 2023
概括
制药研发 (R&D) 在低收入和中等收入国家 (LMICs) 正在扩大,投资和临床试验活动在增加. 有针对性的政策和政府支持对于进一步推动全球南方的创新至关重要.
科学领域:
- 制药创新 制药创新 制药创新
- 全球卫生公平性全球卫生公平性
- 在LMICs中药物开发.
背景情况:
- 关于低收入和中等收入国家 (LMICs) 制药创新活动,能力和成果的数据有限.
- 在LMICs中,全球对制药创新的兴趣日益增长,需要更清楚地了解这个景观.
研究的目的:
- 在LMIC中绘制全球制药研发 (R&D) 活动的地图.
- 分析孟加拉国和哥伦比亚的国家制药创新系统.
- 确定全球南方制药研发的挑战和前景.
主要方法:
- 文学分析,关键信息人采访和公开可用的研发资金数据.
- 通过人力资源和临床试验活动评估科学能力.
- 孟加拉国和哥伦比亚制药创新系统的比较研究.
主要成果:
- 制药研发在许多LMIC中活跃,其中16个国家成为领导者.
- 增加研发投资和不断增长的产能,包括更多的研究机构和外部资金.
- 临床试验数量和LMIC比例显著增加,早期试验活动越来越多.
- 非商业实体主导临床试验资金;在LMICs正在开发创新药物.
- 国家研究强调需要有针对性的研发政策和增加政府支持.
结论:
- 通过对数据源进行三元化,建立了LMIC中制药研发的全面概述.
- 优先考虑制药研发对于解决LMICs的健康需求至关重要.
- 全球南方制药创新的有希望的趋势需要持续专注关注,以充分发挥潜力.
相关概念视频
Issues And Trends In Healthcare Delivery System
5.6K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.6K
Prescription, Nonprescription and Orphan Drugs
740
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
740
Drug Discovery: Overview
7.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.9K
Drug Control Governance: Regulatory Bodies and Their Impact
161
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
161
Structure-Activity Relationships and Drug Design
729
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
729
Pharmacovigilance
850
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
850


