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肌肉miRNAs在基线和对运动的反应中受到性别的影响

Danielle Hiam^1,2, Shanie Landen^2,3, Macsue Jacques²

¹Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.

|November 28, 2023

概括

在基线和运动后观察到骨肌肉微RNA (miRNA) 的性别差异. 这些miRNAs影响肌肉发育和新陈代谢,突出显示它们在性别特异性肌肉表型中的作用.

科学领域:

运动生理学运动生理学
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

骨肌在微RNA (miRNA) 表达上表现出显著的基于性别的差异.
关于骨肌肉中miRNA调节的研究有限,特别是在运动方面.
微RNA对肌肉发育,表型和运动反应至关重要.

研究的目的:

为了研究性别对骨肌肉miRNA在休息和运动后的表达的影响.
为了识别针对高强度间歇运动的性别特异性miRNA变化.

主要方法:

使用Taqman®miRNA阵列测量了42名健康成年人 (23名男性,19名女性) 骨肌中的758个miRNA.
利用混合线性模型来识别性别偏差的miRNA和运动诱导的表达变化.
进行基因标和通路丰富的基分析,并进行miRNA过度表达的功能性测试.

主要成果:

148个miRNA在基线显示出基于性别的差异性表达.
111个miRNAs对急性高强度间歇运动表现出性别特异的反应.
性别偏见的miRNA目标在肌肉增殖,分化和代谢途径方面得到了丰富.

结论:

在骨肌肉miRNA表达方面存在显著的性别差异,无论是在基线还是运动后.
这些miRNAs调节肌肉发育和新陈代谢至关重要的途径.
微RNA是建立性别特异性骨肌肉表型的关键.

关键词:

性差异性差异性差异性差异性差异性差异性差异性骨架肌肉是一个骨肌肉.转录组转录组就是一个转录组.这是一个小RNARNA.

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