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Updated: Jul 9, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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甲基化导向的调节网络决定了突变疾病驱动基因的增强和沉默,并解释了患者间表达变化

Yifat Edrei1, Revital Levy1, Daniel Kaye1

  • 1Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, 9112102, Jerusalem, Israel.

Genome biology
|November 28, 2023
PubMed
概括

DNA甲基化变异显著影响基因表达,导致质母细胞瘤患者之间的差异. 这种表观遗传调节,不仅仅是DNA序列的变化,塑造了复杂的基因调节网络和癌症的发展.

关键词:
癌症驱动基因是癌症的驱动基因.关联监管要素 关联监管要素基因甲基化是DNA的甲基化.增强剂 增强剂 增强剂表达方式的变化.基因调节 基因调节基因调节领域 - 基因调节领域质母细胞瘤 (glioblastoma) 是一个沉默器是一种沉默器.

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