在未接种疫苗的年轻男性中获得新型HPV感染的高风险
Anna R Giuliano1, Joel M Palefsky2, Stephen E Goldstone3
1Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida, USA.
The Journal of infectious diseases
|November 28, 2023
概括
国际上关于男性无遗体人类乳头瘤病毒 (HPV) 感染的数据有限. 这项研究发现,未接种疫苗的年轻男性,特别是与男性发生性关系的男性 (MSM),患有持续性HPV感染的发生率很高,支持性别中立的疫苗接种.
科学领域:
- 流行病学 流行病学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 国际上关于人类乳头瘤病毒 (HPV) 感染在男性中的发病率的数据很少.
- 了解男性HPV流行病学对于公共卫生战略至关重要.
- 无源性HPV感染可以导致男性的各种健康问题.
研究的目的:
- 评估异性恋男性 (HM) 和与男性发生性关系的男性 (MSM) 中发生性持续性 (IP) 无源性HPV感染的发生率.
- 评估由4价值 (4v) 和9价值 (9v) 的HPV疫苗类型引起的感染的发生率.
- 确定年轻男性36个月内IP HPV感染的累积发病率.
主要方法:
- 一个全球性的,多中心的4价值 (4v) HPV疫苗试验安慰剂臂被利用.
- 包括295名与男性发生性关系的男性 (MSM) 和1576名年龄在16-27岁的异性恋男性 (HM).
- 对4vHPV和9vHPV类型的阴茎/阴囊部,周围/周围和门部位的IP无源性HPV感染的发生率估计为4vHPV和9vHPV.
主要成果:
- 在异性恋男性 (HM) 中,每100人/年发生9vHPV类型的发生率在阴茎/阴囊部位为6.8,在周围/周围部位为1.9.
- 在与男性发生性关系的男性 (MSM) 中,每100人/年发生9vHPV类型的发生率为阴茎/阴囊部3.2,周围/周围部9.0,部16.8.
- 超过36个月的累计IP发病率 (任何9vHPV类型) 在MSM (24.1%) 与HM (18.4%) 相比,在MSM中更高.
结论:
- 在未接种疫苗的年轻男性中,很大一部分患有持续的9价值HPV感染.
- 性别中立的HPV疫苗接种可以减少男性的HPV感染.
- 广泛接种疫苗可以有助于群体的保护,并减少与HPV相关的整体疾病负担.
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