在成年羊的B细胞白血病
Adriana P Furtado1, Lindsay M Fry2,3, Lindsay M W Piel2,3
1Veterinary Clinical Sciences, Washington State University, Pullman, Washington, USA.
Veterinary clinical pathology
|November 28, 2023
概括
这份病例报告详细介绍了一只成年绵羊患有罕见的B细胞白血病. 综合诊断证实了诊断,强调了免疫类型的重要性,以准确分类绵羊淋巴瘤新生病.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 乙细胞白血病是成年绵羊的一种罕见的血液性瘤.
- 本报告侧重于疑似急性淋巴细胞白血病的特定病例,该病例发生在5岁的白脸羊身上.
研究的目的:
- 在成年绵羊中报告B细胞白血病病例.
- 强调诊断方法,包括免疫类型,用于准确的分类.
- 突出突发性白血病作为在绵羊淋巴瘤新生病的差异诊断.
主要方法:
- 一个5岁的白脸羊的案例介绍.
- 实验室调查,包括血细胞计数,血清化学,细胞学和组织病理学.
- 免疫组织化学 (CD20标记) 和流细胞测量用于免疫类型.
- 对牛白血病病毒进行查.
主要成果:
- 有标记的白细胞体,淋巴细胞体和血清化学异常.
- 在血液,骨髓,脏,肝脏和肺部中发现的新生性淋巴细胞.
- 免疫组织化学证实了B细胞系 (CD20+);流细胞计验证了B细胞起源.
- 牛白血病病毒查结果为负.
结论:
- B细胞白血病的诊断通过细胞学,组织病理学,免疫组织化学和流动细胞计的结合得到证实.
- 免疫类型定型对于诊断绵羊B细胞白血病至关重要.
- 在患有淋巴瘤瘤的绵羊中,应考虑自发性白血病,特别是在没有感染原因的情况下.
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