补充与孕期高血压和孕前之间的关联:对26项随机对照试验的元分析
Vikash Jaiswal1, Amey Joshi2, Mayank Jha3
1Department of Research, Larkin Community Hospital, South Miami, Fl, USA; JCCR Cardiology Research, Varanasi, India.
Current problems in cardiology
|November 28, 2023
概括
补充可显著降低孕妇产前和妊娠高血压的风险. 这种干预表明了改善母亲和胎儿结果的趋势,强调了它在产前护理中的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 妊娠期间的高血压疾病,包括子前期和子前期,是全球范围内孕产妇和胎儿发病率和死亡率的主要原因.
- 减少妊娠高血压疾病的不良结果是当代孕产妇医疗保健的关键重点.
- 营养干预措施,特别是补充剂在减轻这些风险方面的作用需要彻底调查.
研究的目的:
- 系统地评估补充剂与患妊娠前和妊娠高血压的风险之间的关联.
- 在随机对照试验中分析补充剂对其他母亲和胎儿结局的影响.
主要方法:
- 在主要的电子数据库中进行了全面的系统文献搜索.
- 该搜索包括从开始到2023年7月15日发表的随机对照试验 (RCT).
- 数据被提取并使用几率比率 (OR) 分析,以95%的置信区间 (95%CI) 进行聚合分析.
主要成果:
- 分析包括26个RCT,涉及20038名孕妇 (10,003名接受补充剂,10035名接受安慰剂).
- 补充显著降低了49% (OR,0.51;95% CI:0.40-0.66) 的孕前风险和30%的妊娠高血压 (OR,0.70;95% CI:0.58-0.85).
- 观察到较低的早产,产业诱导,较小的妊娠年龄,低出生体重,围产死亡率和产妇死亡率的趋势,但没有达到统计学意义.
结论:
- 补充剂显示出显著的保护作用,防止先兆子和妊娠高血压.
- 这些发现表明,补充对改善母亲和胎儿的结果有潜在的益处,尽管可能需要进一步的研究来确认二次结果的统计学意义.
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