通过使用酸酸进行外部滑,恶化了冲击粘接
Tianyi Xiang1, Changquan Calvin Sun1
1Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, United States.
International journal of pharmaceutics
|November 28, 2023
概括
用酸 (MgSt) 外部滑令人惊的是,在低压下恶化了制药粉末的冲击粘合. 这项研究通过分析拳头,MgSt和活性药物成分 (API) 之间的力量来解释这种反直觉现象.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 机械工程 机械工程
背景情况:
- 使用酸 (MgSt) 的外部滑是防止在粉末压缩过程中穿孔粘合的标准做法.
- 活性药物成分 (API) 往往具有很高的粘附性,需要滑策略.
研究的目的:
- 为了研究外部MgSt滑对API压缩过程中穿孔粘接的影响.
- 阐明观察到的低压加剧粘结现象背后的潜在机制.
主要方法:
- 使用具有不同机械性质的纯API进行了粉末压缩实验.
- 在不同的压缩压力下评估了穿孔粘接,有或没有MgSt滑.
- 分析的重点是穿孔尖,MgSt和API粒子之间的力量相互作用.
主要成果:
- 外部MgSt滑加剧了在低压缩压力下粘附的冲击,这与预期相反.
- 这种现象依赖于压力,并受到API的机械性质的影响.
- 基于穿孔-API接口的力相互作用开发了一个解释.
结论:
- 石滑并不是普遍有益的,并且在某些API的低压缩压力下可能是有害的.
- 了解力动力学对于优化制药粉压缩中的滑策略至关重要.
- 对压力依赖的滑效应进行进一步的研究是强大的平板电脑制造的必要条件.
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