心血管疾病负担,死亡率和中突然死亡风险:英国生物库研究
Ravi A Shah1, C Anwar A Chahal2, Shaheryar Ranjha3
1London North West University Healthcare NHS Trust, London, United Kingdom.
The Canadian journal of cardiology
|November 28, 2023
概括
中年患者面临更高的心血管疾病风险和显著增加的死亡率,包括突然死亡. 这凸显了迫切需要更好地了解和预防这一群体的预防策略.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 突然死亡是医疗耐药性患者死亡的主要原因.
- 中年患者的死亡风险和心血管疾病 (CVD) 负担仍未得到充分研究.
研究的目的:
- 调查心血管疾病的患病率和评估死亡风险,包括所有原因和突然死亡,中年PWE与非队伍相比.
主要方法:
- 利用了7220个PWE和494,676个对照的英国生物库数据,平均随访时间为12.30年.
- 采用Cox比例危险回归来分析所有原因和突然死亡风险.
- 使用经过验证的诊断代码确定心血管疾病患病率,但不包括先前有中风史的参与者.
主要成果:
- 在PWE中,高血压,冠状动脉疾病,心力衰竭,膜心脏病和先天性心脏病的患病率较高.
- 在PWE中,心律失常 (心房动/动,心房失常,导电缺陷,心室失常) 和心脏植入式电子设备更为常见.
- 经过调整的全因死亡率 (HR 3.9) 和突发死亡特异性死亡率 (HR 6.65) 显著上升,PWE的死亡年龄约为2年.
结论:
- 中年PWE经验增加了所有原因和突然死亡的死亡率,加上更大的心血管疾病负担,包括心律失常和心力衰竭.
- 进一步的研究对于了解PWE死亡率背后的机制以及开发有针对性的预防疗法和预后生物标志物至关重要.
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