艾滋病毒感染者和没有艾滋病毒感染者的COVID-19突破性感染:全州的队列分析
Xueying Yang1, Jiajia Zhang2, Ziang Liu2
1Department of Health Promotion, Education and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, USA; South Carolina SmartState Center for Healthcare Quality, University of South Carolina, Columbia, USA.
概括
艾滋病毒感染者 (PLWH) 和没有艾滋病毒感染者 (PWoH) 之间,COVID-19疫苗的有效性是可比的. 然而,没有强剂量的PLWH显示出突破性感染的风险更高.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 了解COVID-19疫苗在免疫受损人群中的有效性至关重要.
- 艾滋病毒感染者 (PLWH) 可能有免疫反应的改变.
- 评估跨越流行病阶段的突破性感染至关重要.
研究的目的:
- 为了比较艾滋病毒感染者 (PLWH) 与没有艾滋病毒感染者 (PWoH) 的COVID-19突破性感染.
- 分析不同SARS-CoV-2变种和疫苗接种状态的感染风险.
主要方法:
- 使用南卡罗来纳州全州HIV数据的回顾性队列研究 (2021年1月至2022年4月).
- 包括在Alpha,Delta和Omicron变种流通期间完全接种疫苗的成年人 (>18岁).
- 考克斯比例危险模型用于评估艾滋病毒状态与突破性感染之间的关联.
主要成果:
- 在倾向性得分匹配后,艾滋病毒感染和突破性感染率之间没有显著的关联.
- 没有增剂的艾滋病毒感染者 (PLWH) 患有突破性感染的风险更高 (aHR:1.19).
- 在PLWH中,高CD4计数或病毒抑制与突破性感染风险的增加无关.
结论:
- 在艾滋病毒感染者 (PLWH) 中,COVID-19疫苗的有效性并不大大降低.
- 强剂对于减轻PLWH突破性感染风险至关重要.
- 进一步的研究可能会探索PLWH.的细微免疫反应.
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