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Updated: Jul 9, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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在常见的可变免疫缺陷疾病中对基因编辑的挑战:当前和未来的前景.

Rohan Ameratunga1, Euphemia Leung2, See-Tarn Woon3

  • 1Department of Clinical Immunology, Auckland Hospital, Park Rd, Grafton 1010, Auckland, New Zealand; Department of Virology and Immunology, Auckland Hospital, Park Rd, Grafton 1010, Auckland, New Zealand; Department of Molecular Medicine and Pathology, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, New Zealand.

Clinical immunology (Orlando, Fla.)
|November 28, 2023
PubMed
概括

克里斯普尔基因编辑为原发性免疫缺陷 (PID) 提供了潜在的潜力. 虽然常见可变免疫缺陷疾病 (CVID) 缺乏明确的遗传原因,但CRISPR可能有助于调查类似CVID的疾病,并长期治疗它们.

关键词:
克里斯普尔 Cas9 案例在CVID中,我们可以看到.类似于CVID的疾病基因编辑 基因编辑基因毒性 基因毒性

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