扩散型和肠型早期胃癌患者的存活率的比较:一项基于人口的大型研究
1Department of Gastroenterology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.
Medicine
|November 28, 2023
概括
早期出现的胃癌 (EOGC) 存活率因Lauren类型而异. 扩散型EOGC的存活率低于肠型,这凸显了对这种疾病需要增加临床关注的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 关于早期胃癌 (EOGC) 的存活率的知识有限.
- 基于劳伦分类 (扩散与肠道类型) 的EOGC生存率比较的证据很少.
研究的目的:
- 基于劳伦型的EOGC患者的生存差异的调查.
- 确定影响EOGC生存的风险和保护因素.
主要方法:
- 对监测,流行病学和最终结果 (SEER) 数据库的回顾性分析.
- 利用多重归算缺少的数据,多变量考克斯回归,竞争风险模型,卡普兰-梅尔 (K-M) 生存曲线和倾向得分匹配 (PSM).
主要成果:
- 分析包括3932名EOGC患者 (2086名扩散,1846名肠道).
- 分散型EOGC被确定为较差生存率的独立风险因素.
- 年轻的患者 (20-29岁) 的生存率更差. 手术和淋巴结检查是保护因素.
- PSM证实,与肠道型相比,扩散型EOGC患者的生存结果明显较差.
结论:
- 与扩散型EOGC相比,肠道型EOGC显示出更好的生存率.
- 由于其独特的生存特征,EOGC需要更多的临床关注.
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