预防性药物遗传测试的可行性和改善医疗服务不足的患者中药物治疗满意度的可行性
Christelle Lteif1, Elizabeth Eddy1, Joshua Terrell1
1Center for Pharmacogenomics and Precision Medicine and Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
药物遗传学 (PGx) 测试对于医疗服务不足的患者来说是可行的和有益的,改善了治疗满意度和药物坚持. 这项试点研究表明,PGx的实施可以改善不同人群的患者护理.
科学领域:
- 药物基因组学 药物基因组学
- 临床实施科学 临床实施科学
- 健康差异研究 研究健康差异研究
背景情况:
- 医疗服务不足的人群经常接受具有药物遗传学 (PGx) 指南的药物.
- 关于PGx测试对这些特定群体的影响的证据有限.
- 这项研究解决了在服务不足的社区对PGx实施的数据需求.
研究的目的:
- 评估PGx测试在服务不足的人群中的可行性.
- 探索PGx测试的临床和实施结果.
- 评估对患者治疗满意度和药物服药程度的影响.
主要方法:
- 试点研究涉及黑人和拉丁裔患者从门诊诊所.
- 进行了PGx测试,通过招生和可操作的基因型率来衡量可行性.
- 评估的临床结果包括治疗满意度,药物坚持和6个月的提供者接触.
主要成果:
- 96%的患者具有可操作的基因型,其中28%与他们处方的PGx药物有关.
- 患者对治疗的满意度在测试后显著增加.
- 药物坚持和医疗保健提供者的遭遇也显著增加.
结论:
- 预防性PGx测试在缺乏服务的患者的初级保健中是可行的.
- PGx测试改善了患者的满意度和坚持,并增加了提供者的参与度.
- 需要进一步的临床试验来确认在不同人群中长期的影响.
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