血D-二聚物水平与糖尿病病的疾病进展有关:一项两中心队列研究
Yedong Yu1, Caifeng Zhu2, Yi Lin2
1Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Renal failure
|November 28, 2023
概括
在糖尿病病 (DN) 患者中,较高的血D-二聚合物水平与功能恶化和疾病进展风险增加有关. 这一发现凸显了D-二次体作为DN结果的潜在生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 糖尿病学 糖尿病学
- 血液学 血液学 血液学
背景情况:
- 糖尿病病 (DN) 是糖尿病的一个主要并发症,导致损伤.
- 血D-二聚合物是凝血激活的标志物,已被研究其在各种脏疾病中的作用.
研究的目的:
- 为了研究血D-二聚物水平与活检证明的糖尿病病 (DN) 中的临床病理特征之间的关联.
- 确定血D-二聚合物水平与DN患者不良临床结果之间的关系.
主要方法:
- 进行了一项对137名活检证明的DN患者的队列研究.
- 患者根据血D-二次体水平分为三次体.
- 考克斯回归模型被用来评估复合结果的风险 (死亡,40%的e-GFR下降或ESRD),经过调整以考虑混因素.
主要成果:
- 较高的血D-二聚合物水平与24小时蛋白尿的增加,估计较低的淋巴细胞过率 (e-GFR),较高的淋巴细胞损伤类别以及高的间歇性纤维化和管管缩 (IFTA) 评分有关.
- 在较高的血D-二聚物水平和不良临床结果的风险增加之间观察到非线性关联 (趋势的p = .001).
结论:
- DN患者血D-二聚合物水平升高与更严重的损伤和较差的临床病理特征有关.
- 血D-二分体可以作为一个有价值的预后生物标志物,用于预测DN进展和不良结果.
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