在自身免疫血清性贫血中输血:与免疫接种的频率和临床意义
Francesco Versino1,2, Nicoletta Revelli3, Stefania Villa3
1Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Journal of internal medicine
|November 28, 2023
概括
自免疫血清性贫血 (AIHA) 患者可以在适当匹配的情况下安全地输血. 随着时间的推移,输血政策和实践降低了AIHA患者的红细胞输血和合免疫率.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
背景情况:
- 自身免疫血液溶解性贫血 (AIHA) 与输血反应和非免疫化风险有关.
- 了解输血影响对于管理AIHA患者至关重要.
研究的目的:
- 评估AIHA的输血政策和免疫率.
- 评估AIHA患者与免疫接种的临床意义.
主要方法:
- 从305名AIHA患者 (1997-2022) 的回顾性和前性数据收集.
- 对输血需求,反应和对抗体的发展进行分析.
- 几十年来输血率和免疫接种趋势的评估.
主要成果:
- 33%的AIHA患者接受了输血,反应率为83%,输血反应为7%.
- 在19%的患者中检测到阿洛抗体,与更高的输血负担和反应有关.
- 随着时间的推移,红细胞输血率从53%降至20%,免疫接种率从30%降至6%.
结论:
- 严重症状的AIHA患者可以在适当的患者-捐赠者匹配的情况下安全地接受输血.
- 改进的输血策略,包括白血病减少和分子类型,已经显著减少了AIHA的合免疫.
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