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相关概念视频

Self-Schemas02:16

Self-Schemas

31.1K
In general, a schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
31.1K
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

5.2K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.2K
Chromosome Structure02:40

Chromosome Structure

22.8K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
22.8K
The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

49.9K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
49.9K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

11.2K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
11.2K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

20.5K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
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相关实验视频

Updated: Jul 9, 2025

A Customizable Protocol for String Assembly gRNA Cloning STAgR
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A Customizable Protocol for String Assembly gRNA Cloning STAgR

Published on: December 26, 2018

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自引用嵌入字符串 (SELFIES) 库的最新进展

Alston Lo1, Robert Pollice1,2,3, AkshatKumar Nigam4

  • 1Department of Computer Science, University of Toronto Canada alston.lo@mail.utoronto.ca r.pollice@rug.nl alan@aspuru.com.

Digital discovery
|November 28, 2023
PubMed
概括

这项研究引入了SELF引用嵌入字符串 (SELFIES),这是一个强大的分子表示,可以克服SMILES等传统方法中常见的错误. 更新的更新的更新

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Production of Double-stranded DNA Ministrings
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Production of Double-stranded DNA Ministrings

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In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity
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In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity

Published on: March 25, 2020

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相关实验视频

Last Updated: Jul 9, 2025

A Customizable Protocol for String Assembly gRNA Cloning STAgR
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A Customizable Protocol for String Assembly gRNA Cloning STAgR

Published on: December 26, 2018

9.8K
Production of Double-stranded DNA Ministrings
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Production of Double-stranded DNA Ministrings

Published on: February 29, 2016

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In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity
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In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity

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科学领域:

  • 化学信息学 化学信息学
  • 机器学习在化学中的应用
  • 计算化学计算化学

背景情况:

  • 基于字符串的分子表示对于化学信息学至关重要.
  • 像SMILES这样的传统表示通常会从生成模型中产生语法和语义上不正确的输出.
  • 在化学中采用深度学习需要强大的分子表示.

研究的目的:

  • 呈现自拍图书馆的当前状态 (版本 2.1.1).
  • 为了突出SELF引用嵌入字符串 (SELFIES) 表示的进步.
  • 为了展示自拍图书馆的强度,效率和功能方面的改进.

主要方法:

  • 在SELFIES语法的发展和一般化.
  • 在开源自拍图书馆中实现更新的SELFIES表示.
  • 在图书馆设计,效率和功能支持方面进行了改进.

主要成果:

  • 自拍提供了固有的100%稳健的分子表示.
  • 自拍图书馆 (v2.1.1) 支持更广泛的分子和语义约束.
  • 在自拍图书馆的效率和功能方面取得了显著的改进.

结论:

  • 更新后的自拍图书馆为机器学习中的分子表示提供了强大而高效的解决方案.
  • SELFIES有效地解决了传统基于字符串的表示的局限性.
  • 开源自拍图书馆是计算化学和化学信息学研究的宝贵工具.