素促进免疫代谢防御,在败血症期间调解宿主-病原体合作
Robert M Gallant1,2,3,4, Jessica M Snyder5, Janelle S Ayres1,3,4,6
1Molecular and Systems Physiology Lab, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
bioRxiv : the preprint server for biology
|November 28, 2023
概括
选择性血清素再吸收抑制剂 (SSRI) 通过增加干白素-10 (IL-10) 水平,独立于血清素来预防败血症. 这种免疫代谢机制重新编程心脏,提供治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢研究的研究.
- 药理学 药理学是指药理学的学科.
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 是广泛使用的抗抑郁药.
- 除了对中枢神经系统的影响外,SSRI还会影响免疫和代谢功能.
- 以前的研究表明,SSRI可以保护人免受诸如败血症和COVID-19之类的感染,但机制尚不清楚.
研究的目的:
- 阐明SSRI流素保护抗败血症的机制.
- 为了研究外周血清素和IL-10在西的败血症保护中的作用.
- 为了确定fluoxetine免疫代谢效应的潜在治疗应用.
主要方法:
- 利用了毒症的动物模型.
- 测量了fluoxetine对外周血清素和IL-10水平的影响.
- 评估了IL-10的必要性,以防止心脏中因败血症引起的代谢变化.
主要成果:
- 素中介性对败血症的保护独立于周围的血清素.
- 素显著增加了循环中的互白素-10 (IL-10) 水平.
- IL-10对于预防与败血症相关的高甘油三血症和心脏甘油三积累至关重要,促进心脏代谢重编程.
结论:
- 西通过涉及IL-10的"非目标"免疫代谢机制提供了败血症保护.
- 这项研究揭示了IL-10在败血症引起的代谢功能障碍中的新型保护作用.
- 这些发现突出了利用SSRI来管理败血症和相关代谢并发症的潜在治疗策略.
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