毒素菌含有一种对低氧反应有反应的基基氨基酸脱酶类蛋白质
Melanie Key1,2, Carlos Gustavo Baptista3, Amy Bergmann1
1Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA, 29634.
bioRxiv : the preprint server for biology
|November 28, 2023
概括
毒素菌具有在低氧状态下起作用的基脱酶 (CPDH). 尽管TgCPDH具有酶活性和对低氧的反应,但它不会影响寄生虫的生长或病原性.
科学领域:
- 分子寄生虫学 分子寄生虫学
- 代谢适应 代谢适应
- 尾复合生物学的生物学
背景情况:
- 毒素菌会引起毒素菌症,这是免疫力低下个体的严重疾病.
- 寄生虫的生存需要对不同的环境进行代谢适应,包括缺氧.
- 淋巴细胞毒素合成血红素,对于细胞内生存至关重要,使用coproporphyrinogen III氧化酶 (CPOX).
结论:
- 这项研究报告了第一个在真核生物中发现的基基脱酶类蛋白质.
- TgCPDH表现出酶活性并对低氧反应,但不会影响Toxoplasma gondii的发病.
- 在Toxoplasma gondii的生命周期和适应中TgCPDH的作用需要进一步研究.
相关概念视频
Necrosis
4.5K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.5K
Exon Recombination
3.6K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
3.6K
Protein Import into the Peroxisomes
3.5K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
3.5K


