在致病性Leptospira感染期间,人类的托尔类受体2 (TLR2) 反应
C N Kappagoda1, Rmisk Senevirathne2, D Jayasundara3
1Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka.
bioRxiv : the preprint server for biology
|November 28, 2023
概括
人类类似收费受体2 (TLR2) 基因表达在白病患者中被分析. 研究结果表明,在急性人类白病中TLR2的下调,与典型的实验室发现形成鲜明对比.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 分子生物学分子生物学
背景情况:
- 人的先天免疫依赖于与病原体相关的分子模式相互作用的模式识别受体.
- 收费类受体2 (TLR2) 在小鼠白病模型中至关重要,但人类数据很少.
- 这项研究调查了人类白病例中的TLR2表达.
研究的目的:
- 为了确定确诊的白皮病患者的类似收费受体2 (TLR2) 基因表达特征.
- 为了比较人类TLR2响应在临床白病与实验模型的既定发现.
主要方法:
- 通过qPCR确认了经过qPCR识别的牛皮螺旋菌病例.
- 从全血样本中提取的RNA.
- 人类TLR2基因表达量化使用RT-qPCR并与参考基因 (GAPDH,B2M,HPRT1) 进行正常化.
主要成果:
- 对初始队列中的18名患者的分析显示,有一例TLR2基因下调.
- 在另一个由13名患者组成的队列中,有3名患者表现出TLR2基因下调.
- 在大多数患者中,没有观察到TLR2表达的显著变化或上调.
结论:
- 人类急性勒托西症与下调的TLR2基因表达有关.
- 这与Leptospira感染的体外和体内实验模型的发现形成鲜明对比.
- 需要进一步的研究,以阐明TLR2在临床LeptoSpirosis发病的机制.
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