在V1的侧向抑制控制神经和感知对比度敏感性
bioRxiv : the preprint server for biology
|November 28, 2023
概括
视觉皮层的侧向抑制使用不同的神经元类型来处理视觉对比. 帕瓦胺 (PV) 神经元提供减法抑制,而体静止素 (SST) 神经元调整灵敏度的增加.
科学领域:
- 神经科学是一个神经科学.
- 视觉系统研究 视觉系统研究
- 感官处理 感官处理
背景情况:
- 侧向抑制对于感官处理至关重要,通过激活抑制性神经元来精炼神经信号.
- 不同类型的抑制神经元,如PV和SST神经元在皮质侧面抑制中的特定作用及其对感知的影响仍然不清楚.
- 了解主要视觉皮层 (V1) 中的这些机制对于理解视觉感知至关重要.
研究的目的:
- 调查小鼠V1中parvalbumin (PV) 和somatostatin (SST) 神经元介导的侧向抑制如何影响神经和感知对视觉对比度的敏感性.
- 从PV与SST神经元中区分横向抑制的计算作用和空间范围.
主要方法:
- 在小鼠初级视觉皮层 (V1) 中的电生理学记录 (V1).
- 行为实验测量对视觉对比度的感知敏感性.
- 神经电路的计算建模. 神经电路的计算建模.
- 解剖学追踪和下值测量以确定抑制神经元的空间足迹.
主要成果:
- 来自PV神经元的侧向抑制均地降低了神经和感知对对比度的敏感性.
- 来自SST神经元的侧向抑制调节了神经和感知对比度灵敏度的斜率 (收益).
- 与PV神经元相比,SST神经元表现出空间广泛的横向投射,这是通过建模和解剖学数据证实的.
结论:
- 在V1横向抑制中,PV和SST神经元在V1横向抑制中发挥着不同的,细胞类型特定的计算作用.
- 这些不同的角色显著影响视觉对比度的处理,这是一个基本的视觉属性.
- 横向抑制的空间范围是区分PV和SST神经元的功能影响的关键因素.
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