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基因编码LYTACs的定向进化用于细胞介导的传递

Jonathan Lee Yang¹, Sean A Yamada-Hunter², Louai Labanieh^3,2

¹Department of Chemistry and Sarafan ChEM-H, Stanford University, Stanford, CA, USA.

bioRxiv : the preprint server for biology

|November 28, 2023

概括

我们通过用类似胰岛素的增长因子2 (IGF2) 替换合成来开发出一种可遗传编码的化体向化体 (GELYTAC). 在特定的疾病部位,分泌GELYTAC的工程免疫细胞使得向蛋白质降解成为可能.

科学领域:

生物技术是生物技术.
分子生物学分子生物学
治疗开发的治疗方法

背景情况:

lysosome-targeting chimeras (LYTACs) 提供了一种细胞外蛋白质降解的方法.
目前的LYTACs使用合成糖,限制了它们的治疗整合和遗传编码.
存在需要基因编码LYTACs用于蜂应用和有针对性的交付.

结论:

杰利塔克代表了一种用于向蛋白质降解的新型,可遗传编码的工具.
从工程免疫细胞中分泌的GELYTAC可用于空间选择性治疗应用.
这项技术有望推进向蛋白质降解疗法.

关键词:

细胞疗法是一种细胞疗法.化学生物学是化学生物学.有针对性的蛋白质降解降解.合成生物学合成生物学

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