认知能力和大脑形态之间的双向效应:生活过程 门德尔的随机化分析
Roxanna Korologou-Linden1,2, Isabel K Schuurmans3,4, Charlotte A M Cecil3,4,5,6
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom.
medRxiv : the preprint server for health sciences
|November 28, 2023
概括
认知能力和大脑形态表现出整个生命的双向影响. 幼儿时期和成年期揭示了最早的影响,强调童年作为干预的关键时期.
科学领域:
- 神经科学是一个神经科学.
- 人类发展 人类发展
- 遗传学 是一个遗传学.
背景情况:
- 大脑结构与整个生命周期的认知功能之间的关系尚未得到充分理解.
- 以前的研究往往侧重于一般的大脑测量,忽视了区域差异.
研究的目的:
- 通过不同的生命阶段,研究认知能力和大脑形态之间的双向关系.
- 检查与认知能力相关的全球和区域大脑结构差异.
主要方法:
- 在一个大队列 (N=37,864) 中利用门德尔的随机化来评估因果关系.
- 分析了对估计的总内体积,皮质厚度,表面积,白质量和皮质下体积的影响.
- 跨发育时期的分层分析:童年,早期成年期和中后期成年期 (8-81岁).
主要成果:
- 在所有生命阶段发现认知能力,总内体积和总表面积之间的双向联系.
- 在童年和早期成年期观察到的前面对面区域的早期影响.
- 特定的区域关联:较厚的后侧环状皮质和较大的尾部中前端/极表面积与较高的认知相关;较厚的极与较低的认知相关.
结论:
- 认知能力会在整个生命周期中持续影响大脑形态.
- 儿童时期成为针对大脑发育和认知功能的干预措施的潜在关键时期.
关键词:
这是ABCD的ABCD.在阿尔斯帕克 (ALSPAC) 地区.认知能力 认知能力这一代是R世代,R世代是R世代.在IMAGEN中,我们可以看到.门德尔的随机化英国生物银行大脑储备储备是什么?大脑结构 大脑结构生命的过程 生命的过程更多相关视频
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