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KSR1淘汰赛小鼠模型证明了MAPK途径在西斯和噪音引起的听力损失中的关键作用

Matthew A Ingersoll¹, Richard D Lutze¹, Regina G Kelmann¹

¹Department of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.

bioRxiv : the preprint server for biology

|November 28, 2023

概括

消除RAS 1 (KSR1) 的蛋白激酶抑制剂或抑制MAPK通路,可以防止因西斯和噪音造成的听力损失. 这为保护听力提供了潜在的治疗策略.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

听力损失是全球严重的残疾,需要有效的治疗干预措施.
RAS 1 (KSR1) 的蛋白激酶抑制剂在耳细胞对损伤的反应中起作用.

结论:

这种依赖于KSR1的MAPK通路对于调解西斯普拉丁和噪音引起的听力损失至关重要.
准MAPK途径是一个有希望的治疗策略,用于预防和治疗听力损失.
对MAPK信号的药理抑制为保护听力提供了一种可行的方法.

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相关概念视频

MAPK Signaling Cascades

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...