步行速度是与癌症相关的缓冲症下降和恢复的生物标志物
bioRxiv : the preprint server for biology
|November 28, 2023
概括
步行速度,而不是握力,准确地反映了癌症缓解症的功能衰退. 这一发现对于开发有效疗法和改善临床试验中患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
- 生物医学研究生物医学研究
背景情况:
- 癌症相关的缓解症的特征是逐渐的功能衰退.
- 目前的疗法面临的翻译挑战是由于不充分的功能评估在 cachectic 患者.
- 现有的癌症模型和结果指标,如握力,无法准确地捕捉功能缺陷.
研究的目的:
- 开发和验证癌症缓冲症的临床前模型,准确反映功能衰退.
- 为了比较步行速度与握力之间的实用性,作为临床前和临床缓解症研究中的结果指标.
- 确定可靠的生物标志物,以评估癌症缓解症中的功能障碍.
主要方法:
- 开发了一种低剂量正规化 (LO) KPC 鼠标模型,模仿卡赫西亚相关的肌肉损耗和炎症.
- 通过步行速度 (通过6分钟步行测试) 和握力评估LO动物的功能下降.
- 在接受康复的156名癌症患者中,功能测量与缓解症严重程度的相关功能测量,使用与功能独立度 (FIM) 相比的握力和步行速度.
主要成果:
- LO模型显示了骨和心脏肌肉的逐渐衰竭和全身炎症.
- 在LO动物中早期观察到步行速度下降,并与缓解症相关联.
- 在卡切克症患者中,6分钟步行测试 (6MWT) 的变化与FIM分数有显著的相关性,与握力不同.
结论:
- 步行速度是癌症缓解症功能衰退的更敏感和具体的衡量标准,而不是握力.
- 基于步态的评估是未来临床前和临床缓解症研究的首选.
- 改善功能结果的措施对于推进缓解症疗法至关重要.
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02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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