Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

General Transcription Factors01:30

General Transcription Factors

5.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.3K
Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

15.5K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
15.5K
Transcription Factors02:16

Transcription Factors

75.9K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
75.9K
Position-effect Variegation02:32

Position-effect Variegation

6.3K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.3K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

23.3K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
23.3K
Gene-Environment Interactions01:20

Gene-Environment Interactions

328
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
328

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map.

Genome research·2026
Same author

High-resolution, genotype-free mapping of genetic variation with CRI-SPA-Map.

bioRxiv : the preprint server for biology·2025
Same author

Genotype-by-environment interactions shape ubiquitin-proteasome system activity.

Genetics·2025
Same author

Genotype-by-environment interactions shape ubiquitin-proteasome system activity.

bioRxiv : the preprint server for biology·2024
Same author

Assembly, stability, and dynamics of the infant gut microbiome are linked to bacterial strains and functions in mother's milk.

bioRxiv : the preprint server for biology·2024
Same author

Substrate-specific effects of natural genetic variation on proteasome activity.

PLoS genetics·2023
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jul 9, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.3K

跨-eQTL热点通过调节细胞状态来塑造复杂的特征.

Kaushik Renganaath1, Frank W Albert1

  • 1Department of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN 55455, USA.

bioRxiv : the preprint server for biology
|November 28, 2023
PubMed
概括
此摘要是机器生成的。

影响基因表达的遗传变异显著影响复杂的特征. 我们的研究表明,跨作用调节热点,而不是局部变异,是酵母生长中这些连接的关键驱动因素.

关键词:
遗传变异是一种遗传变异.在IRA2中,IRA2是IRA2.在 QTL 时段,你会得到 QTL.我们的eQTL是eQTL.调解 调解 是一种调解方式.类型的类型.定量遗传学 定量遗传学

更多相关视频

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.9K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.1K

相关实验视频

Last Updated: Jul 9, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.3K
Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.9K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.1K

科学领域:

  • 遗传学 遗传学 是一个
  • 系统生物学 系统生物学
  • 分子生物学分子生物学

背景情况:

  • 调节性遗传变异影响基因表达,将DNA变异与复杂的特征联系起来.
  • 基因表达和复杂特征之间的确切因果关系尚未得到充分理解.
  • 对于从医学到进化生物学等各个领域来说,理解这些联系至关重要.

研究的目的:

  • 研究酵母菌中基因表达和复杂生长特征之间的关系.
  • 确定基因表达变异的基因架构及其对复杂特征的影响.
  • 阐明局部与跨作用调节变异在塑造复杂特征中的作用.

主要方法:

  • 在酵母交叉 (Saccharomyces cerevisiae) 中整合了转录基因数据与46个遗传复杂的生长特征.
  • 分析基因表达和生长特征之间的遗传相关性.
  • 区分地方监管变化的贡献与多个独立的跨作用位置的贡献.

主要成果:

  • 在基因表达和酵母菌生长之间发现了成千上万的遗传相关性.
  • 局部调节变异是较小的贡献者;跨作用的调节位置是遗传相关性的主要来源.
  • 跨作用调节热点显著影响了基因生长变异和基因表达-生长相关性,影响了许多基因.

结论:

  • 跨作用调节热点是通过调节细胞状态来决定复杂特征的主要决定因素.
  • 了解这些热点可以了解遗传变异如何转化为表型多样性.
  • 这项研究强调了非局部监管要素在塑造生物复杂性的重要性.