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Updated: Jun 18, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
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在3xTg-AD小鼠中,VTA多巴胺神经元由于素激酶2-依赖SK通道功能障碍导致过度兴奋,3xTg-AD小鼠中,VTA多巴胺神经元过度兴奋

Harris E Blankenship1,2, Kelsey A Carter1, Nina T Cassidy1,3

  • 1Aging and Metabolism Research Program, Oklahoma Medical Research Foundation.

bioRxiv : the preprint server for biology
|November 28, 2023
PubMed
概括

中脑多巴胺神经元功能障碍有助于阿尔茨海默病 (AD) 症状. 抑制素激酶2 (CK2) 能使神经元活动正常化,从而提供一种潜在的新型AD治疗方法.

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Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants


Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...