增强CAR-T细胞代谢以克服脑瘤微环境中的缺氧状况
bioRxiv : the preprint server for biology
|November 28, 2023
概括
结合甲胺和拉帕米辛可以增强脑瘤中CAR-T细胞的功能. 这种组合改善了T细胞代谢和在低氧瘤环境中的生存,提高了抗质瘤的疗效,并在临床前模型中延长了生存时间.
科学领域:
- 免疫治疗是一种免疫疗法.
- 癌症生物学 癌症生物学
- 代谢工程是代谢工程.
背景情况:
- 化学抗原受体 (CAR) -T细胞疗法对脑瘤的疗效有限,原因是免疫抑制和缺氧瘤微环境.
- 大脑瘤中的CAR-T细胞表现出线粒体功能受损和ATP生产减少,与外围瘤中的细胞相比.
结论:
- 在低氧脑瘤模型中,Met+Rap预处理改善了CAR-T细胞代谢适应性和抗质瘤功效.
- 这些发现支持对Met+Rap预处理的CAR-T细胞进行临床研究,用于治疗脑瘤.
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