高脂肪饮食促进腹膜炎症,并增加与子宫内膜异位症相关的腹部过敏症
Tristin Herup-Wheeler1, Mingxin Shi1, Madeleine E Harvey1
1School of Molecular Bioscience, Center for Reproductive Biology, Washington State University, Pullman, WA 99614, USA.
bioRxiv : the preprint server for biology
|November 28, 2023
概括
高脂肪饮食 (HFD) 通过增加炎症和改变肠道微生物群,加剧子宫内膜异位症相关的疼痛. 通过增强炎症反应和疼痛调解剂,HFD会加剧子宫内膜异位症中的过敏症.
科学领域:
- 生殖免疫学 生殖免疫学
- 胃肠病学 胃肠病学
- 疼痛研究 疼痛研究
背景情况:
- 免疫功能障碍和慢性炎症是子宫内膜异位症发展的关键因素.
- 西式高脂肪饮食 (HFD) 与全身炎症和代谢疾病有关.
- HFD是妇科疾病的潜在环境风险因素.
研究的目的:
- 研究HFD如何影响子宫内膜异位症的炎症环境.
- 确定HFD对子宫内膜异位症相关过敏症的贡献.
主要方法:
- 在子宫内膜异位症的小鼠模型中评估腹部机械.
- 腹膜巨细胞和细胞因子水平的分析.
- 评估背部根性质中与疼痛相关的调解物.
- 检查肠道微生物群的组成和多样性.
主要成果:
- 由HFD诱导的肥胖症加剧了与子宫内膜异位症相关的机械合性.
- 慢性HFD摄入增加了腹膜炎性巨细胞和细胞因子的损伤后诱导.
- 此外,HFD还刺激了背部根的与疼痛相关的介质.
- HFD改变了肠道微生物群的多样性和组成,表明低级系统性炎症.
结论:
- HFD通过增强炎症和疼痛信号来加剧与子宫内膜异位症相关的过敏症.
- 虽然不单独发起盆腔炎症,但HFD有助于恶化子宫内膜异位症的慢性炎症.
- 由于HFD引起的肠道微生物群变化在全身炎症和疼痛恶化中起作用.
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