驱动红外线睡眠-觉醒和躁狂类行为节奏的神经元
Pratap S Markam1,2, Clément Bourguignon1,2, Lei Zhu2
1Integrated Program in Neuroscience, McGill University; Montreal QC H3A 2B4, Canada.
bioRxiv : the preprint server for biology
|November 28, 2023
概括
双极性障碍 (BD) 循环可能涉及红外线节奏. 暴露于甲基胺的小鼠表现出这些节奏,这些节奏取决于腹膜区域 (VTA) 的多巴胺 (DA) 神经元向核 (NAc) 投射.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 的特点是情绪和睡眠-觉醒障碍与红外节律 (周期≥48小时).
- 这些节奏即使在时间隔离中也持续存在,这表明其源自内生源.
- 了解这些节奏的神经机制对于建模BD循环至关重要.
研究的目的:
- 研究多巴胺 (DA) 途径在产生与双相情感障碍 (BD) 循环相关的红外线节奏中的作用.
- 建立一个小鼠模型来研究BD相关的红外线节奏.
主要方法:
- 在饮用水中,小鼠暴露在甲基胺 (Meth) 中,以诱导红外线节律.
- 进行了DA神经元在腹部 tegmental 区域 (VTA) 的 DA 生产的遗传干扰和核 accumbens (NAc) 投射 DA 神经元的切除.
- 使用了NAc投射DA神经元的化学遗传激活.
- 监测了NAc的DA过程中的运动活动,睡眠模式和细胞质.
主要成果:
- 在小鼠中,甲基胺暴露诱导了运动活动,睡眠时间和躁狂类行为中的红外节奏.
- 干扰VTA DA神经元中的DA产生或消灭NAc投射的DA神经元取消了这种循环能力.
- 投射NAc的DA神经元的化学遗传激活在缺乏时钟的小鼠中延长了运动运动周期.
- 在NAc DA过程中的细胞质与运动行为同步波动.
结论:
- BD 循环与红外线节奏生成有关.
- 投射NAc的DA神经元对于产生这些红外线节奏至关重要.
- 这项研究提供了一个新的小鼠模型,用于调查双相情感障碍循环的神经生物学基础.
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