牙周炎与正常认知中年和老年人的大脑结构和功能的改变有关
Xiaoshu Li1, Yufei Tao2, Hui Li1
1Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Journal of periodontal research
|November 28, 2023
概括
牙周炎与认知正常的老年人中大脑结构和功能变化有关. 这种牙疾病可能是认知能力下降和脑损伤的早期风险因素.
科学领域:
- 神经科学是一个神经科学.
- 牙周病学 牙周病学
- 老年学是一门学科.
背景情况:
- 牙周炎是阿尔茨海默病的疑似危险因素.
- 牙周炎与老年人的正常认知之间的联系仍然不清楚.
- 了解这种联系可能有助于了解阿尔茨海默病的发展见解和预防策略.
研究的目的:
- 调查正常认知老年人牙周健康和大脑结构/功能之间的关联.
- 使用多式磁共振成像 (MRI) 来评估大脑指标.
主要方法:
- 收集了40名具有正常认知能力的老年人的高分辨率T1加权结构MRI,休息状态功能MRI和牙周数据.
- 使用DPABISurf计算的皮质体积,厚度,面积和区域均性.
- 在成像指标和牙周指标之间进行了相关性分析.
主要成果:
- 严重的牙周炎与皮质体积,区域和主要和高级认知区域的厚度有负相关性.
- 轻微的依附损失和浅的口袋深度显示与大脑结构/功能有积极的相关性.
- 严重的依附性损失和深的口袋深度显示与大脑结构/功能 (p < .005) 有负相关性.
结论:
- 牙周炎与认知正常的中年和老年人的大脑结构和功能发生显著变化有关.
- 这些发现表明牙周炎可能是脑损伤的潜在危险因素.
- 需要进一步的研究来探索对认知健康和神经退行性疾病预防的影响.
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