发生心血管疾病的血蛋白概况:多样本评估
Lars Lind1, Olga Titova2, Rui Zeng1
1Department of Medical Sciences (L.L., R.Z., S.G., J.S.), Uppsala University, Sweden.
Circulation. Genomic and precision medicine
|November 28, 2023
概括
蛋白质基因分析确定了与心血管疾病 (CVD) 相关的新型血蛋白,包括心肌梗塞,中风和心力衰竭. 一个由11种蛋白质组成的小组改善了心血管疾病预测,表明了共享的疾病途径.
科学领域:
- 心血管科学 心血管科学
- 蛋白质组学是指蛋白质组学.
- 生物标志物发现发现
背景情况:
- 心血管疾病 (CVD) 是一个严重的健康负担.
- 蛋白质基因分析为发现新的心血管疾病病理生理路径和改善个体风险预测提供了潜力.
研究的目的:
- 调查与心肌梗塞,中风和心力衰竭发病率相关的血蛋白质概况.
- 确定用于心血管疾病风险分层的新型蛋白质生物标志物.
主要方法:
- 分析了来自瑞典四个基于人口的队列 (SIMPLER,ULSAM,EpiHealth,POEM) 的11,869名个体的血蛋白水平.
- 使用发现/验证方法来识别与复合CVD终点 (心肌梗塞,中风,心力衰竭) 相关的蛋白质.
- 对个别心血管疾病结果进行了元分析,并使用拉索选择评估了预测模型.
主要成果:
- 42种蛋白与复合CVD终点相关.
- 对心肌梗塞 (49种蛋白质),缺血性中风 (34种蛋白质) 和心力衰竭 (109种蛋白质) 发现了显著的关联.
- 13种蛋白质,包括损伤分子1 (KIM-1),泌尿酸酶等离子素激活器表面受体和上腺素,与所有三种结局和亚临床心血管疾病标志物有关.
- 一个由11种蛋白质组成的小组在与传统风险因素相加时,可提高3.3%的心血管疾病预测.
结论:
- 蛋白质基因分析确定了与心肌梗塞,中风和心力衰竭相关的新型血蛋白,这表明了常见的潜在病理生理机制.
- 损伤分子1 (KIM-1),泌尿酸酶等离子激素激活器表面受体,上腺素成为潜在的CVD早期生物标志物.
- 一个由11种蛋白质组成的精选小组证明了增强心血管疾病风险歧视的潜力.
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