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Updated: Jul 9, 2025

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在in-silicon模型中不同基本假设对DNA损伤和修复预测的影响

John W Warmenhoven1,2, Nicholas T Henthorn1,2, Aimee L McNamara3

  • 1Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.

Radiation research
|November 28, 2023
PubMed
概括

对DNA双链断裂 (DSB) 的计算模型进行比较,揭示了初始损伤假设如何影响癌症放射治疗的预测. 标准化数据格式对于精确的DNA修复和细胞死亡的in silico建模至关重要.

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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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