由于大麻叶蒸发器的气溶损害了内皮功能
Jiangtao Liu1,2, Pooneh Nabavizadeh1, Poonam Rao2,3
1Cardiovascular Research Institute, University of California, San Francisco San Francisco CA USA.
Journal of the American Heart Association
|November 28, 2023
概括
大麻叶蒸发剂,尽管被认为更安全,但损害了老鼠的血管内皮功能,类似于大麻烟. 这表明,蒸汽大麻并不能减少与吸烟有关的心血管风险.
科学领域:
- 心血管科学 心血管科学
- 肺部病理学 肺部病理学
- 毒理学 毒理学 毒理学
背景情况:
- 大麻叶蒸发器是吸食大麻的流行的替代品,通常被认为不那么有害.
- 以前的研究表明,烟草和大麻的烟雾以及电子烟和加热烟草制品的气溶可以损害血管内皮功能.
研究的目的:
- 为了研究大麻叶蒸发剂气溶对大鼠血管内皮功能的影响.
- 为了比较蒸发器气溶对大麻烟雾和清洁空气暴露的影响.
主要方法:
- 鼠被暴露在两种不同的大麻蒸发器 (火山和约坎) 的气溶中,温度和大麻素水平各不相同.
- 血管内皮功能被测量为动脉流介导扩张 (FMD).
- 通过在模拟的住宅室环境中将老鼠暴露在稀释的气溶中,模拟了二手暴露.
主要成果:
- 暴露在大麻叶蒸发剂气溶中,无论温度或大麻素含量如何,大鼠的口炎明显减弱约50%.
- 无论是直接的还是模拟的二手暴露在蒸发器气溶中,都表明内皮功能受损程度与大麻烟相比较.
- 暴露在清洁空气或水蒸气中并没有影响口病.
结论:
- 对大麻叶蒸发剂气溶的急性直接和二手暴露会损害老鼠内皮功能,类似于大麻烟雾.
- 使用大麻叶蒸发器不太可能减轻与吸食大麻相关的血管风险.
- 与吸烟相比,蒸发器的使用可能不是一个比吸烟更安全的心血管健康选择.
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