癌症幸存者的心脏病死亡率:日本的一项基于人口的研究
Yasufumi Gon1,2, Ling Zha3, Tsutomu Sasaki1
1Department of Neurology Osaka University Graduate School of Medicine, Suita Osaka Japan.
Journal of the American Heart Association
|November 28, 2023
概括
与普通人群相比,癌症幸存者面临的致命心脏病风险要高得多. 这种风险,特别是缺血性心脏病和心力衰竭的风险,最近呈现下降.
科学领域:
- 心血管流行病学心血管流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 关于癌症患者心血管相关死亡风险的数据有限.
- 了解癌症幸存者的非癌症死亡率对于综合护理至关重要.
研究的目的:
- 在日本的癌症患者中调查致命心脏病的风险.
- 为了比较癌症患者与普通人群的心血管死亡率.
- 分析癌症幸存者心脏病死亡率的趋势和风险因素.
主要方法:
- 使用大阪癌症登记和日本生命统计 (1985-2013) 的回顾性队列研究.
- 分析死亡原因,计算标准化死亡率 (SMRs) 并使用Fine和Gray竞争风险模型.
- 包括682,886名癌症患者,分析了335,635例死亡.
主要成果:
- 心脏病是非癌症死亡的主要原因 (10,686例).
- 心脏病的总体SMR为2.80;缺血性心脏病 (3.26),心力衰竭 (2.69),高血压疾病 (5.97) 的特定SMR升高.
- 癌症诊断后致命心脏病的风险增加;男性的风险更高 (SHR=1.08). 近年来,风险已经下降.
结论:
- 与普通人群相比,癌症幸存者患致命心脏病的风险要高得多.
- 特定的心脏病,如高血压疾病,造成不成比例地更高的风险.
- 虽然风险仍然很高,但最近的趋势表明,癌症幸存者中致命的心脏病的发生率有所下降.
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