生命的基本8与心血管疾病和死亡率的关联:弗雷明汉心脏研究
Athanasios Rempakos1, Brenton Prescott2, Gary F Mitchell3
1Minneapolis Heart Institute Foundation Minneapolis MN.
Journal of the American Heart Association
|November 28, 2023
概括
美国心脏协会的生命必需8 (LE8) 评分有效预测心血管疾病 (CVD) 和成人死亡风险. 保持高的LE8得分与较低的风险有关,而持续低的得分表明风险更高.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 美国心脏协会更新的心血管健康指标Life's Essential 8 (LE8) 在弗雷明汉心脏研究 (FHS) 队列中没有得到评估.
- 现有的研究缺乏关于LE8得分与心血管疾病 (CVD) 或FHS人群死亡率之间的关联的数据.
研究的目的:
- 评估生活必需品8 (LE8) 评分及其随时间变化与心血管疾病 (CVD) 和死亡风险的关联.
- 为了比较LE8得分的预测能力与前一个Life's Simple 7 (LS7) 在Framingham心脏研究后代队列中的得分.
主要方法:
- 该研究分析了没有心血管疾病的Framingham Offspring参与者 (n=2888在第二次考试中,n=1667在第六次考试中).
- 使用考克斯的比例危险模型,将LE8分数及其在2和6次检查之间的变化与心脏病发病率和死亡率联系起来.
- 参与者根据LE8得分进行分类,并将风险关联与从Life's Simple 7得分中得出的风险关联进行比较.
主要成果:
- 在检查2时观察到平均LE8得分为67分. 与LE8分数≥68的参与者相比,与得分<68.8的参与者相比,心血管疾病 (HR,0.47) 和死亡 (HR,0.55) 的风险显著降低.
- 与LS7.7相比,在使用LE8时,相当一部分参与者 (60%) 被重新分类为不同的心血管健康状况,而不是LS7.
- 在整个研究期间,持久低LE8分数的个体表现出患心血管疾病和死亡的最高风险.
结论:
- 生活必需品8 (LE8) 评分显示,在弗雷明汉心脏研究队列中,与心血管疾病 (CVD) 和死亡风险存在显著关联.
- LE8评分似乎是评估心血管健康和预测长期结果的宝贵工具.
- 建议进行进一步的研究,以确定LE8得分在风险预测方面的优越性,而不是Life's Simple 7得分.
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