在人类免疫缺陷病毒感染的急性冠状动脉综合征后的死亡率与最佳坚持:全国性的研究
Hyemin Jung1, Eunyoung Lee2, Jun-Soo Ro1
1Department of Health Policy and Management, College of Medicine, Seoul National University, Seoul, Korea.
Infection & chemotherapy
|November 28, 2023
概括
接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染者 (PWH) 患有急性冠状动脉综合征 (ACS) 的风险更高. 然而,在ART坚持最佳时,ACS后的死亡率与一般人群相似.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 很少有研究在同时接受抗逆转录病毒疗法 (ART) 的人类免疫缺陷病毒 (HIV) 患者中检查急性冠状动脉综合征 (ACS) 结果.
- 在艾滋病毒感染者 (PWH) 中,普遍使用ART和病毒抑制是常见的.
研究的目的:
- 为了评估在PWH中以最佳的ART坚持的情况下发生动脉样硬化心血管事件 (ACS) 后的死亡率.
- 为了比较PWH和普通人群之间的ACS发病率和结果.
主要方法:
- 使用的韩国国民健康保险索赔数据 (2009-2019).
- 确定了新诊断的PWH和评估了ART的坚持.
- 在PWH中证实了ACS和死亡率,具有最佳的坚持.
主要成果:
- 与一般人群相比,与最佳ART坚持相比,PWH的ACS发生率是PWH的1.3倍.
- 在PWH中ACS的相关因素包括艾滋病,高血压,失脂症和糖尿病.
- 在ACS后的整体死亡率为7.1% (心肌梗塞为2.9%),与一般人群相比.
结论:
- 保持最佳ART坚持的PWH表现出更高的ACS患病率.
- 在最佳ART的PWH中,ACS后的死亡率与HIV阴性个体相比较.
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