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Updated: Jul 9, 2025

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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多基因风险评分修改了非洲祖先男性的致病变体的前列腺癌风险

Raymond W Hughley1, Marco Matejcic1, Ziwei Song2

  • 1Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.

Cancer research communications
|November 28, 2023
PubMed
概括

在ATM,BRCA2,PALB2和NBN基因的罕见变异显著影响前列腺癌的风险. 将罕见变异状态与多基因风险评分 (PRS) 结合起来,可以改善非洲血统男性的前列腺癌风险评估.

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相关概念视频

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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