在患有多发性硬化症的人群中,呼吸道肌肉强度测量的可靠性和最小可检测变化
Sandra Aguilar-Zafra1, Raúl Fabero-Garrido, Tamara Del Corral
1Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Motion in Brains Research Group, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Spain, and Téxum S.L. Physiotherapy Center, Coslada, Madrid, Spain (S.A.Z.); Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, Madrid, Spain (R.F.G.); and Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Universidad Complutense de Madrid, IdISSC, Madrid, Spain (T.d.C., I.L.d.U.V.).
呼吸道肌肉强度测量在多发性硬化症 (MS) 患者中表现出卓越的可靠性. 较强的呼吸肌肉与较低的残疾和呼吸障碍相关,改善生活质量.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 康复医学 康复医学 康复医学
背景情况:
- 呼吸道肌肉衰弱是多发性硬化症 (MS) 的一个问题.
- 在MS中呼吸肌力 (RMS) 测量的可靠性和临床意义尚未得到充分确立.
- 需要进一步调查RMS和功能结果之间的关联.
研究的目的:
- 在患有多发性硬化症的个体中确定RMS措施的测试-重新测试可靠性和最小可检测变化 (MDC).
- 检查RMS与与健康有关的生活质量 (HRQoL),残疾,呼吸障碍和体育活动之间的关联.
- 调查在MSMS中不同残疾水平的RMS差异.
主要方法:
- 61名多发性硬化症患者接受了两次评估,隔7-10天.
- 通过最大吸入和呼气压力 (MIP/MEP) 测量呼吸肌肉强度.
- 评估的HRQoL (EuroQol-5D-5L),残疾 (EDSS),呼吸障碍 (MRC) 和体力活动 (IPAQ).
主要成果:
- RMS测量显示出优异的测试重复测试可靠性 (ICC ≥ 0.92).
- 已建立的MDC:MIP为15.42cmH2O,MEP为17.84cmH2O. 这两种数值均为MDC.
- 较高的RMS与更好的HRQoL相关 (r = 0.540.62),以及较低的残疾 (r ≤ -0.66) 和呼吸障碍 (r ≤ -0.61).
- 在残疾水平之间观察到RMS的显著差异 (P < 0.01,d ≥ 0.73).
结论:
- 呼吸道肌肉强度测量对于MS患者来说是可靠的.
- MDCs为评估RMS变化提供了临床相关的基准.
- 呼吸道肌肉强度显著影响残疾和呼吸障碍,影响MS中的HRQoL.
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