肠道微生物群和血清代谢组的年龄相关变化与功能和人类衰老有关
Liang Sun1, Zhiming Li2,3,4,5, Caiyou Hu6
1The NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, China.
Aging cell
|November 28, 2023
概括
衰老会损害功能,可能是由于肠道微生物. 这项研究将特定的肠道细菌及其代谢物与与年龄相关的脏衰退联系起来,老年人群的便微生物群移植证实了这一点.
科学领域:
- 微生物学 微生物学
- 老年学是一门学科.
- 代谢学 代谢学 代谢学
背景情况:
- 人的衰老与功能下降有关.
- 来自肠道微生物的尿液毒素可能会加剧与年龄相关的功能障碍.
- 肠道微生物群,代谢物和衰老之间的相互作用仍然不完全理解.
研究的目的:
- 为了研究肠道微生物群和血清代谢组的年龄相关变化.
- 为了识别与衰老中功能受损相关的微生物和代谢物标志物.
- 探索肠道微生物群与与年龄相关的功能下降之间的因果关系.
主要方法:
- 在22-111岁的中国长寿队列 (n=151) 中,综合性肠道微生物群和血清代谢组概况.
- 在独立的日本 (n=330) 和云南 (n=80) 衰老队列中验证.
- 调解分析和便微生物群移植实验.
主要成果:
- 在肠道微生物群和血清代谢组中发现了与年龄相关的显著差异.
- 肠道微生物群对血清代谢物的影响随着年龄的增长而增加.
- 特定的肠道细菌 (例如,大肠杆菌) 和代谢物 (例如,p-cresol) 与受损功能标志物有关.
- 来自老年人的便微生物群影响了接受者的功能标志物.
结论:
- 取决于年龄的肠道微生物群变化与血清代谢物标记器功能受损有关.
- 微生物群-代谢物相互作用在与年龄相关的功能下降中起着至关重要的作用.
- 这些发现提供了通过微生物群调节来保持衰老期间脏健康的见解.
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