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基底或刺激的甲状腺蛋白在评估皮肤状甲状腺癌治疗的反应? 一个回顾性队列研究

Leticia Barreto¹, Deborah Cristina Goulart Ferreira¹, José Eduardo Corrente²

¹Internal Medicine Department, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Brazil.

Hormones (Athens, Greece)

|November 28, 2023

概括

刺激型甲状腺蛋白 (STg) 测量是治疗1年后与基底型甲状腺蛋白 (BTg) 相比,在乳头甲状腺癌 (PTC) 患者中更好地预测出色的反应. 在约20%的病例中,STg改变了反应评估,这表明其具有卓越的临床实用性.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
核医学是一种核医学.

背景情况:

乳头甲状腺癌 (PTC) 的管理包括监测治疗反应.
甲状腺蛋白 (Tg) 水平是关键标志物,但测量方法 (基底与刺激) 不同.

研究的目的:

为了比较基底铁血球蛋白 (BTg) 和刺激铁血球蛋白 (STg) 与PTC患者治疗反应的相关性.
确定STg是否是初始治疗后长期良好反应的更好预测因素.

主要方法:

对148名接受全甲状腺切除和放射性 (131I) 治疗的PTC患者进行了回顾性分析.
评估治疗反应 (优秀,生化不完整,不确定) 在一年后使用BTg和STg.
比较BTg与STg的预测值,以在最终评估时获得优异反应.

主要成果:

刺激型甲状腺蛋白 (STg) 与拟议的结果相关的比基底型甲状腺蛋白 (BTg) 的1.6倍.
对于STg的几率比为4.61 (95%CI:2.13-9.98) 与BTg的2.84 (95%CI:1.33-6.06) 相比.
大约20.4%的患者在使用STg与BTg相比使用STg时显示出响应评估的变化.

结论:

一年后的刺激性甲状腺蛋白 (STg) 测量是PTC患者良好反应的更可靠预测指标.
使用STg可以改变大量患者的治疗反应分类,提高预后准确性.

关键词:

生物标志物,瘤的生物标志物临床演变的临床演变预测预后预测预测甲状腺球蛋白是一种甲状腺蛋白.甲状腺癌,乳头癌,乳头癌.

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