最佳的心血管健康与较慢的认知衰退有关
Naomi Vidal Ferreira1,2, Natalia Gomes Gonçalves3, Claudia Szlejf1
1Center for Clinical and Epidemiological Research, Hospital Universitario, Universidade de Sao Paulo, Sao Paulo, Brazil.
European journal of neurology
|November 28, 2023
概括
包括睡眠在内的生活必需品8 (LE8) 评分与较慢的认知衰退有关. 更高的LE8分数,特别是由于更好的血糖和血压,可以防止认知衰老.
科学领域:
- 心血管健康和认知功能
- 公共卫生与老龄化问题
背景情况:
- 衡量心血管健康的指数Life's Simple 7 (LS7) 已更新为Life's Essential 8 (LE8),包括睡眠.
- 虽然LS7与认知功能有关,但LE8与认知的关联仍在调查中.
研究的目的:
- 检查生活必需品8 (LE8) 评分与随时间推移的认知衰退之间的关联.
- 确定LE8的哪些组成部分对认知健康产生最显著的影响.
主要方法:
- 巴西成人健康纵向研究 (ELSA-巴西) 队列的纵向分析.
- 根据饮食,体育活动,尼古丁暴露,睡眠健康,BMI,血脂,血糖和血压来评估LE8分数.
- 在8年内使用多项测试评估认知能力,包括口语流和执行功能,并通过线性混合模型分析进行分析.
主要成果:
- 较高的基线LE8分数与全球认知,记忆和口语流性下降的速度较慢有关.
- 这种关联主要是由LE8的健康相关因素驱动的,特别是血糖和血压.
- 年龄,性别和种族改变了这种关联,在老年,男性和黑人参与者中具有更明显的保护作用.
结论:
- 对生命必需8项的更高坚持与在8年内保持认知功能有关.
- 血糖和血压是LE8中影响认知衰老的关键可修改因素.
- 社会人口统计学因素在LE8和认知衰退之间的关系中发挥着作用.
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