COVID-19疫苗接种和复发活动:丹麦多发性硬化症患者的一项全国性队列研究
Dominika Stastna1,2, Frederik Elberling2, Luigi Pontieri2
1Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
European journal of neurology
|November 28, 2023
概括
接种COVID-19疫苗并没有增加复发性多发性硬化症的丹麦患者的复发率. 这项研究发现,在第一剂疫苗接种后,复发发生率或年度复发率没有显著变化.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 复发性多发性硬化症 (MS) 需要监测疾病活动.
- 对于患有多发性硬化症的人来说,建议接种COVID-19疫苗.
- 疫苗对MS复发的潜在影响是一个关键问题.
研究的目的:
- 评估COVID-19疫苗接种前后复发性MS患者复发发生的变化.
- 评估COVID-19疫苗在MS疾病活性方面的安全性.
主要方法:
- 丹麦复发性多发性硬化症患者的全国性队列研究.
- 在COVID-19疫苗第一剂前和后90天和180天内复发率的比较.
- 使用回归模型分析年度复发率 (ARR).
主要成果:
- 疫苗接种后90天 (1.3%对1.4%) 或180天 (2.7%对2.6%) 复发比例没有统计学意义上的差异.
- 与疫苗接种前的比率相比,ARR没有显著变化.
- 与更高的复发风险相关的因素包括年轻年龄,更高的残疾和以前的复发.
结论:
- 第一剂COVID-19疫苗没有导致复发性多发性硬化症患者的复发活性增加.
- 研究结果支持该人群中COVID-19疫苗接种的安全性.
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