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甲状腺器官的构建和应用方面的进展
1Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. sunny68@hust.edu.cn.
Physiological research
|November 28, 2023
概括
甲状腺有机体,从3D培养的干细胞中自我组织,模仿器官结构. 本综述涵盖了它们的构建和在研究甲状腺疾病发展中的使用.
科学领域:
- 生物医学工程 生物医学工程
- 发展生物学 发展生物学
- 内分泌学 在内分泌学.
背景情况:
- 有机体是3D多细胞培养物,它们从干细胞中自我组织.
- 它们复制器官的解剖结构和功能单元.
- 甲状腺有机体为研究甲状腺生物学提供了一个新的模型.
研究的目的:
- 审查甲状腺器官的施工方法.
- 总结使用甲状腺器官在疾病建模中的研究进展.
- 突显有机体对理解甲状腺疾病病原体的有用性.
主要方法:
- 在三维 (3D) 环境中培养干细胞.
- 细胞的自我组织成有机结构.
- 应用有机体模型来研究与甲状腺有关的疾病.
主要成果:
- 成功构建功能性甲状腺器官.
- 使用有机体的甲状腺疾病建模的进展.
- 有机器人对疾病机制提供了洞察力.
结论:
- 甲状腺有机体是生物医学研究的宝贵工具.
- 它们提供了一个3D多细胞环境,用于研究甲状腺病原性.
- 器官技术有助于理解和潜在的治疗甲状腺疾病.
相关概念视频
01:23The Thyroid Gland
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
01:20Synthesis and Regulation of Thyroid Hormones
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...