Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.9K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.9K
Caspases01:24

Caspases

12.5K
Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
12.5K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

9.9K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
9.9K
Genetic Screens02:46

Genetic Screens

5.0K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.0K
Synthetic Biology02:55

Synthetic Biology

4.8K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
4.8K
CRISPR and crRNAs02:53

CRISPR and crRNAs

17.0K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
17.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Effects of micronized bamboo powder on performance, nutrient utilization, intestinal histology, and cecal microbiota in laying hens.

Frontiers in microbiology·2026
Same author

Complete cox 1 gene and ITS sequence of Hirudinaria manillensis and molecular evolution analysis.

Scientific reports·2025
Same author

Quality Grading of "Fubaiju" Based on Inflorescence Diameter and Content of Polyphenolic Substances.

ACS omega·2025
Same author

Analysis of the response mechanism in lipid degradation of key gene LDH1 knockout strains of Saccharomyces cerevisiae under levulinic acid stress.

Archives of microbiology·2025
Same author

ND-FISH with New Oligo Probes for Chromosome Identification of <i>Cichorium intybus</i> Revealing Karyotypic Variation and Divergence of Asteraceae Species.

Plants (Basel, Switzerland)·2024
Same author

Genome-wide analysis of fatty acid desaturase genes in moso bamboo (Phyllostachys edulis) reveal their important roles in abiotic stresses responses.

BMC genomics·2024

相关实验视频

Updated: Jul 9, 2025

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
10:19

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project

Published on: April 8, 2017

17.5K

iCAZyGFADB:一种昆虫的CAZyme和基因功能注释数据库.

Chun Fu1, YaoJun Yang1

  • 1Key Laboratory of Sichuan Province for Bamboo Pests Control and Resource Development, Leshan Normal University, No. 778 Binhe Road, Shizhong District, Leshan, Sichuan 614000, China.

Database : the journal of biological databases and curation
|November 28, 2023
PubMed
概括

iCAZyGFADB是一个免费,快速和全面的数据库,集成了九个基因功能注释工具. 它显著提高了基因组研究的效率,因为它可以同时注释单一物种的八个基因功能.

科学领域:

  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.
  • 计算生物学 计算生物学

背景情况:

  • 高通量测序产生了大量的生物基因组数据.
  • 有效和用户友好的工具对于功能基因注释至关重要.
  • 现有的平台往往缺乏全面的注释功能或为高级功能收费.

研究的目的:

  • 开发一个完整的生物基因组功能注释的数据库网站.
  • 提供一个用户友好的平台,多个基因功能注释工具.
  • 提高基因组功能研究的效率,降低基因组功能研究的成本.

主要方法:

  • 整合了九种不同的基因功能注释工具:碳水化合物活性酶 (CAZyme),基因本体学 (GO),基因和基因组的京都百科全书 (KEGG),正基因集群 (COG),基因的进化基因谱:无监督正基因组 (eggNOG),瑞士Prot,Pfam,KOG和动物转录因子数据库 (AnimalTFDB).
  • 为可访问的注释服务开发一个基于网络的平台.
  • 对单个物种的多个基因功能的同时注释的功能实施.

主要成果:

  • 成功开发了iCAZyGFADB,一个集成9个基因功能注释工具的数据库.
  • 与其他生物云分析平台相比,该平台提供了快速的基因功能注释.

更多相关视频

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.8K
Embryo Microinjection and Knockout Mutant Identification of CRISPR/Cas9 Genome-Edited Helicoverpa Armigera H&#252;bner
06:37

Embryo Microinjection and Knockout Mutant Identification of CRISPR/Cas9 Genome-Edited Helicoverpa Armigera Hübner

Published on: July 1, 2021

4.5K

相关实验视频

Last Updated: Jul 9, 2025

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
10:19

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project

Published on: April 8, 2017

17.5K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.8K
Embryo Microinjection and Knockout Mutant Identification of CRISPR/Cas9 Genome-Edited Helicoverpa Armigera H&#252;bner
06:37

Embryo Microinjection and Knockout Mutant Identification of CRISPR/Cas9 Genome-Edited Helicoverpa Armigera Hübner

Published on: July 1, 2021

4.5K
  • 所有注释功能都是免费的,并可供用户访问.
  • iCAZyGFADB可以同时注释一个物种的八个基因功能 (GO,KEGG,COG,eggNOG,SwissProt,Pfam,KOG,AnimalTFDB).

    • 结论:

    • iCAZyGFADB为基因组功能注释提供了一种优越且具有成本效益的解决方案.
    • 该数据库显著提高了基因组功能研究的效率.
    • 它是全球基因组功能注释研究人员的宝贵资源.