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Updated: Jun 24, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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abYpap:使用梯度增强回归改进了对抗体VH/VL包装的预测

Veronica A Boron1, Andrew C R Martin1

  • 1Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.

Protein engineering, design & selection : PEDS
|November 28, 2023
PubMed
概括

我们开发了abYpap,这是一种改进的机器学习方法,用于预测抗体变量区域 (Fv) 域包装角度. 这通过先进的特征选择提高了对抗体特异性和结合亲和力的理解.

关键词:
在VH/VL包装中.抗体是对抗体的重要组成部分.机器学习是机器学习.建模建模是什么意思预测 预测 预测 预测

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Overview
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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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